HIF-2α-IN-3 |
| カタログ番号GC62418 |
HIF-2α-IN-3、低酸素誘導因子のアロステリック阻害剤-2α。 (HIF-2α)、0.4 μM の IC50 および 1.1 μM の KD を示します。抗がん剤。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 313964-19-1
Sample solution is provided at 25 µL, 10mM.
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HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent[1].
HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain[1].
[1]. Rogers JL, et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J Med Chem. 2013 Feb 28;56(4):1739-47.
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