الصفحة الرئيسية>>Signaling Pathways>> Microbiology & Virology>> HCV>>Inarigivir soproxil (SB9200)

Inarigivir soproxil (SB9200) (Synonyms: SB9200; GS-9992)

رقم الكتالوجGC30794

Inarigivir soproxil (SB9200) (SB9200) هو ناهض للمناعة الفطرية ويظهر نشاطًا قويًا مضادًا للفيروسات ضد متغيرات HCV المقاومة ، مع EC50s 2.2 و 1.0 μ ؛ M لـ HCV 1a / 1b في خلايا من النمط الجيني 1 HCV أنظمة ريليكون.

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Inarigivir soproxil (SB9200) التركيب الكيميائي

Cas No.: 942123-43-5

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
627٫00
متوفر
5mg
405٫00
متوفر
10mg
639٫00
متوفر
25mg
1170٫00
متوفر
50mg
2025٫00
متوفر
100mg
2909٫00
متوفر

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مراجعات العميل

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Inarigivir soproxil is an agonist of innate immunity and shows potent antiviral activity against resistant hepatitis C virus (HCV) variants, with EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems.

Inarigivir soproxil (SB 9200) is an oral modulator of innate immunity that is believed to act via the activation of the RIG-I and NOD2 pathways. SB 9200 has broad-spectrum antiviral activity against RNA viruses including hepatitis C virus (HCV), norovirus, respiratory syncytial virus and influenza and has demonstrated activity against hepatitis B virus (HBV). Inarigivir soproxil is shown to inhibit HCV replication and the range of inhibition is comparable between genotypes 1a and 1b. Inarigivir soproxil demonstrates pan-genotypic antiviral activity against HCV. Inarigivir soproxil is active against DAA-resistant HCV variants[1].

[1]. Jones M, ET AL. SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants. J Med Virol. 2017 Sep;89(9):1620-1628.

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