Inarigivir soproxil (SB9200) (Synonyms: SB9200; GS-9992) |
| カタログ番号GC30794 |
イナリギビル ソプロキシル (SB9200) (SB9200) は自然免疫のアゴニストであり、遺伝子型 1 の HCV レプリコン システムの細胞における HCV 1a/1b の EC50 が 2.2 および 1.0 で、耐性のある HCV バリアントに対して強力な抗ウイルス活性を示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 942123-43-5
Sample solution is provided at 25 µL, 10mM.
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Inarigivir soproxil is an agonist of innate immunity and shows potent antiviral activity against resistant hepatitis C virus (HCV) variants, with EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems.
Inarigivir soproxil (SB 9200) is an oral modulator of innate immunity that is believed to act via the activation of the RIG-I and NOD2 pathways. SB 9200 has broad-spectrum antiviral activity against RNA viruses including hepatitis C virus (HCV), norovirus, respiratory syncytial virus and influenza and has demonstrated activity against hepatitis B virus (HBV). Inarigivir soproxil is shown to inhibit HCV replication and the range of inhibition is comparable between genotypes 1a and 1b. Inarigivir soproxil demonstrates pan-genotypic antiviral activity against HCV. Inarigivir soproxil is active against DAA-resistant HCV variants[1].
[1]. Jones M, ET AL. SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants. J Med Virol. 2017 Sep;89(9):1620-1628.
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