Inarigivir soproxil (SB9200) (Synonyms: SB9200; GS-9992) |
| Catalog No.GC30794 |
L'inarigivir soproxil (SB9200) (SB9200) est un agoniste de l'immunité innée et présente une activité antivirale puissante contre les variants résistants du VHC, avec des CE50 de 2,2 et 1,0 μM pour le VHC 1a/1b dans les cellules des systèmes de réplicons du VHC de génotype 1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 942123-43-5
Sample solution is provided at 25 µL, 10mM.
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Inarigivir soproxil is an agonist of innate immunity and shows potent antiviral activity against resistant hepatitis C virus (HCV) variants, with EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems.
Inarigivir soproxil (SB 9200) is an oral modulator of innate immunity that is believed to act via the activation of the RIG-I and NOD2 pathways. SB 9200 has broad-spectrum antiviral activity against RNA viruses including hepatitis C virus (HCV), norovirus, respiratory syncytial virus and influenza and has demonstrated activity against hepatitis B virus (HBV). Inarigivir soproxil is shown to inhibit HCV replication and the range of inhibition is comparable between genotypes 1a and 1b. Inarigivir soproxil demonstrates pan-genotypic antiviral activity against HCV. Inarigivir soproxil is active against DAA-resistant HCV variants[1].
[1]. Jones M, ET AL. SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants. J Med Virol. 2017 Sep;89(9):1620-1628.
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