Indisulam (Synonyms: E-7070) |
| رقم الكتالوجGC65549 |
Indisulam (E 7070) هو مثبط كربونيك أنهيدراز مع نشاط مضاد للسرطانIndisulam (E 7070) هو عامل سلفوناميد يستهدف المرحلة G1 من دورة الخليةيتسبب Indisulam (E 7070) في حدوث حصار في انتقال G1 / S من خلال تثبيط تنشيط كل من CDK2 و cyclin E. Indisulam (E 7070) أهداف الربط عن طريق إحداث تدهور RBM39 عن طريق التوظيف في DCAF
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Cas No.: 165668-41-7
Sample solution is provided at 25 µL, 10mM.
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Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15[1][2].
Indisulam (E7070, 0-50 μg/mL, 12-48 h) causes cell cycle perturbation in the G1 phase in a time- and dose-dependent manner, potentially leading to cell death[1].
Indisulam (E7070, 12.5, 25, 50 (100) mg/kg) shows an antitumour spectrum in human cancer models[1].
[1]. Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer. 2001 Nov;37(17):2275-82.
[2]. Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23.
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