KS 176 |
رقم الكتالوجGC14688 |
KS 176 هو مثبط قوي وانتقائي لبروتين مقاومة سرطان الثدي (BCRP) الناقل متعدد الأدوية (قيم IC50 هي 0.59 و 1.39 ميكرومتر في فحوصات Pheo A و Hoechst 33342 على التوالي). لا يعرض أي نشاط مثبط ضد P-gp أو MRP1.
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Cas No.: 1253452-78-6
Sample solution is provided at 25 µL, 10mM.
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.IC50 value: 0.59( in Pheo A assay), 1.39 μM (in Hoechst 33342 assay).Target: BCRPThe more detailed information please refer to Compound 9 in the reference.
References:
[1]. Pick A, et al. Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem. 2010 Sep 3;5(9):1498-505.
Average Rating: 5
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