Laminaran |
| رقم الكتالوجGC39259 |
Laminaran هو β ؛ -1-3-glucan و ligand نموذجي لـ Dectin-1 من Eisenia Bicyclis ، له أنشطة مناعية قوية ومضادة للأشعة ومضادة للسرطان. يتكون Laminaran من β ؛ (1→؛ 3) -جلوكان مع β ؛ (1→؛ 6) - الفروع ويمكن تحفيزها بواسطة إنزيمات مثل أميناريناز (EC 3.2.1.6) التي تكسر β ؛ (1→؛ 3) السندات. Laminaran هو جزيء محفز مناعي واعد يستخدم في العلاج المناعي للسرطان.
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Cas No.: 9008-22-4
Sample solution is provided at 25 µL, 10mM.
Laminaran is a neutral water-soluble β-1-3-glucan and a typical ligand for Dectin-1 isolated from the brown alga D. dichotoma, has potent immunomodulating, radioprotective, and anticancer activities[1]. Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds[2]. Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy[3].
[1]. Malyarenko OS, et al. Laminaran from brown alga Dictyota dichotoma and its sulfated derivative as radioprotectors and radiosensitizers in melanoma therapy.Carbohydr Polym. 2019 Feb 15;206:539-547. [2]. Laminaran [3]. Song K, et al. Laminarin promotes anti-cancer immunity by the maturation of dendritic cells.Oncotarget. 2017 Jun 13;8(24):38554-38567.
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