Laminaran |
| Catalog No.GC39259 |
Le laminaran est un β-1-3-glucane et un ligand typique de la dectine-1 d'Eisenia Bicyclis, possède de puissantes activités immunomodulatrices, radioprotectrices et anticancéreuses. Laminaran est composé de β (1→3)-glucane avec β (1→6)-ramifications et peut être catalysée par des enzymes telles que lalaminarinase (EC 3.2.1.6) qui rompt le β (1→3) obligations. Le laminaran est une molécule immunostimulante prometteuse pour une utilisation dans l'immunothérapie du cancer.
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Cas No.: 9008-22-4
Sample solution is provided at 25 µL, 10mM.
Laminaran is a neutral water-soluble β-1-3-glucan and a typical ligand for Dectin-1 isolated from the brown alga D. dichotoma, has potent immunomodulating, radioprotective, and anticancer activities[1]. Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds[2]. Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy[3].
[1]. Malyarenko OS, et al. Laminaran from brown alga Dictyota dichotoma and its sulfated derivative as radioprotectors and radiosensitizers in melanoma therapy.Carbohydr Polym. 2019 Feb 15;206:539-547. [2]. Laminaran [3]. Song K, et al. Laminarin promotes anti-cancer immunity by the maturation of dendritic cells.Oncotarget. 2017 Jun 13;8(24):38554-38567.
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