Lenalidomide-propargyl-C2-NH2 hydrochloride |
| رقم الكتالوجGC38808 |
يشتمل هيدروكلوريد Lenalidomide-propargyl-C2-NH2 على يجند cereblon (CRBN) لـ E3 ubiquitin ligase ، ورابطيمكن استخدام هيدروكلوريد Lenalidomide-propargyl-C2-NH2 لتصميم PROTAC MD-224
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Cas No.: 2489242-23-9
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 [1].
[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466.
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