LG 100268 (Synonyms: AGN 192620, CD3127) |
| رقم الكتالوجGC44059 |
LG 100268 (LG268) هو ناهض لمستقبلات الريتينويد X (RXR) قويًا وانتقائيًا ونشطًا عن طريق الفم بقيم EC50 تبلغ 4 نانومتر و 3 نانومتر و 4 نانومتر لـ RXR-α و RXR-β و RXR-، على التوالي.
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Cas No.: 153559-76-3
Sample solution is provided at 25 µL, 10mM.
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LG 100268 is an agonist of retinoid X receptors (RXRs; Kd = 3 nM). It is selective for RXRs over retinoic acid receptors (RARs; Kd = >10,000 nM). In vitro, LG 100268 (1 µM) induces apoptosis in HL-60 human leukemia cells when used in combination with TTNPB . LG 100268 (100, 300, and 1,000 nM) dose-dependently inhibits COX-2 expression and increases ATP-binding cassette transporter (ABCA1) levels in macrophage-like RAW 264.7 cells. In vivo, it inhibits vinyl carbamate-induced lung tumor growth in mice when administered at a dose of 40 mg/kg.
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