LG 100268 (Synonyms: AGN 192620, CD3127) |
| Catalog No.GC44059 |
LG 100268(LG268)은 RXR-α, RXR-β 및 RXR-γ에 대해 각각 4nM, 3nM 및 4nM의 EC50 값을 갖는 강력하고 선택적이며 경구 활성인 레티노이드 X 수용체(RXR) 작용제입니다.
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Cas No.: 153559-76-3
Sample solution is provided at 25 µL, 10mM.
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LG 100268 is an agonist of retinoid X receptors (RXRs; Kd = 3 nM). It is selective for RXRs over retinoic acid receptors (RARs; Kd = >10,000 nM). In vitro, LG 100268 (1 µM) induces apoptosis in HL-60 human leukemia cells when used in combination with TTNPB . LG 100268 (100, 300, and 1,000 nM) dose-dependently inhibits COX-2 expression and increases ATP-binding cassette transporter (ABCA1) levels in macrophage-like RAW 264.7 cells. In vivo, it inhibits vinyl carbamate-induced lung tumor growth in mice when administered at a dose of 40 mg/kg.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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