LLP-3 |
| رقم الكتالوجGC44080 |
LLP-3 هو أحد مثبطات Survivin القوية التي تعطل تفاعل Survivin-Ran في الخلايا السرطانيةيمكن استخدام LLP-3 في البحث عن الورم الأرومي الدبقي متعدد الأشكال (GBM)
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Cas No.: 1453835-43-2
Sample solution is provided at 25 µL, 10mM.
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Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 µM). It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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