LLP-3 |
| カタログ番号GC44080 |
LLP-3 は、がん細胞における Survivin-Ran 相互作用を阻害する強力な Survivin 阻害剤です。 LLP-3 は、多形性膠芽腫 (GBM) の研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1453835-43-2
Sample solution is provided at 25 µL, 10mM.
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Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 µM). It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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