Maprotiline HCl (Synonyms: Ba 34276) |
| رقم الكتالوجGC12376 |
مابروتيلين حمض الهيدروكلوريك هو مثبط انتقائي لإعادة امتصاص النورادرينالين ومضاد للاكتئاب رباعي الحلقات.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 10347-81-6
Sample solution is provided at 25 µL, 10mM.
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Maprotiline hydrochloride is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.Target: OthersMaprotiline (sold as Deprilept, Ludiomil, Psymion) is a tetracyclic antidepressant (TeCA). However, Maprotiline's fourth ring is spurious, as formed by a bridge across the central tricyclic ring. It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake. It exerts strong blocking effect at H1 receptors, moderate at 5-HT2 and alpha1 and weak blocking effect at D2 and mACh postsynaptic receptors [1, 2].
References:
[1]. Peng, W.H., et al., Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life Sci, 2007. 81(11): p. 933-8.
[2]. http://en.wikipedia.org/wiki/Maprotiline
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