Maprotiline HCl (Synonyms: Ba 34276) |
| Catalog No.GC12376 |
Maprotiline HCl is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 10347-81-6
Sample solution is provided at 25 µL, 10mM.
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Maprotiline hydrochloride is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.Target: OthersMaprotiline (sold as Deprilept, Ludiomil, Psymion) is a tetracyclic antidepressant (TeCA). However, Maprotiline's fourth ring is spurious, as formed by a bridge across the central tricyclic ring. It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake. It exerts strong blocking effect at H1 receptors, moderate at 5-HT2 and alpha1 and weak blocking effect at D2 and mACh postsynaptic receptors [1, 2].
References:
[1]. Peng, W.H., et al., Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life Sci, 2007. 81(11): p. 933-8.
[2]. http://en.wikipedia.org/wiki/Maprotiline
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