MI-389 |
| رقم الكتالوجGC64651 |
MI-389 هو عامل إنهاء ترجمة GSPT1 من PROTACيعطل MI-389 هدفًا يمثل تبعية مشتركة في مختلف خطوط الخلايا AML وجميع خطوط الخلايا ، ويعتمد إجراء MI-389 على CRL4CRBN E3 ligase
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Cas No.: 2222635-92-7
Sample solution is provided at 25 µL, 10mM.
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MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase[1].
[1]. Ishoey M, et al. Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders. ACS Chem Biol. 2018;13(3):553-560.
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