MitoPQ (Synonyms: MitoParaquat) |
| رقم الكتالوجGC44204 |
MitoPQ عبارة عن دورة الأكسدة والاختزال التي تستهدف الميتوكوندرياتنتج MitoPQ أكسيدًا فائقًا عن طريق تدوير الأكسدة والاختزال في موقع الفلافين للمركب I ، مما يزيد بشكل انتقائي من إنتاج الأكسيد الفائق داخل الميتوكوندريايمكن استخدام MitoPQ في دراسة مضادات الأكسدة
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Cas No.: 1821370-28-8
Sample solution is provided at 25 µL, 10mM.
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MitoPQ is comprised of a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.[1] Driven by membrane potential, it accumulates selectively in the mitochondrial matrix where it produces superoxide by redox cycling at the flavin site of complex I.[1] Thus, MitoPQ selectively increases superoxide production within mitochondria and can be used as a tool either in cells or in vivo to investigate the role of mitochondrial superoxide in pathology and redox signaling.[1]
Reference:
[1]. Robb, E.L., Gawel, J.M., Aksentijevic, D., et al. Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology & Medicine 89, 883-894 (2015).
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