MitoPQ (Synonyms: MitoParaquat) |
| カタログ番号GC44204 |
MitoPQ は、ミトコンドリアをターゲットとしたレドックスサイクラーです。 MitoPQ は、複合体 I のフラビン部位でレドックス サイクリングによってスーパーオキシドを生成し、ミトコンドリア内のスーパーオキシド生成を選択的に増加させます。 MitoPQ は、抗酸化研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1821370-28-8
Sample solution is provided at 25 µL, 10mM.
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MitoPQ is comprised of a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.[1] Driven by membrane potential, it accumulates selectively in the mitochondrial matrix where it produces superoxide by redox cycling at the flavin site of complex I.[1] Thus, MitoPQ selectively increases superoxide production within mitochondria and can be used as a tool either in cells or in vivo to investigate the role of mitochondrial superoxide in pathology and redox signaling.[1]
Reference:
[1]. Robb, E.L., Gawel, J.M., Aksentijevic, D., et al. Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology & Medicine 89, 883-894 (2015).
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