ML 382 (Synonyms: VU0485891) |
| رقم الكتالوجGC50248 |
ML 382 عبارة عن مُعدِّل خيفي إيجابي قوي وانتقائي MRGPRX1 (مستقبلات مقترنة بالبروتين G المرتبط بـ Mas X1 ، MrgX1) ، مع EC50 من 190 نانومتر.
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Cas No.: 1646499-97-9
Sample solution is provided at 25 µL, 10mM.
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Selective MRGPRX1 positive allosteric modulator (EC50 = 190 nM). Exhibits selectivity for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters. Enhances BAM (8-22) potency at MRGPRX1 by 7-fold.
Wen et al (2015) Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 10 57 PMID:25209672
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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