ML 382 (Synonyms: VU0485891) |
| Catalog No.GC50248 |
ML 382 es un modulador alostérico positivo potente y selectivo de MRGPRX1 (receptor X1 acoplado a proteína G relacionado con Mas, MrgX1), con una EC50 de 190 nM.
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Cas No.: 1646499-97-9
Sample solution is provided at 25 µL, 10mM.
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Selective MRGPRX1 positive allosteric modulator (EC50 = 190 nM). Exhibits selectivity for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters. Enhances BAM (8-22) potency at MRGPRX1 by 7-fold.
Wen et al (2015) Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 10 57 PMID:25209672
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