Monazomycin (Synonyms: Takacidin,U-0142) |
رقم الكتالوجGC10708
One-Click Copy Product Info
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Monazomycin هو مضاد حيوي شبيه بالبوليين تنتجه Streptomyces
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 11006-31-8
Sample solution is provided at 25 µL, 10mM.
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Monazomycin is a positively charged and polyenelike antibiotic produced by Streptomyces [1].
Monazomycin is able to induce a voltage-dependent conductance in lipid bilayer membranes. Monazomycin is selective for monovalent cations and can alter the membrane conductance when applied to one or both sides of the membrane [1]. Application of micromolar amounts of monazomycin on one side of phospholipid bilayer membranes induced dramatic voltage-dependent conductance effects. The steady-state conductance was proportional to the 5th power of the monazomycin concentration and increased exponentially with positive voltage (monazomycin side positive); there was an e-fold change in conductance per 4–6 mv. The major current-carrying ions were univalent cations. Monazomycin monomers cooperated to form a multimolecular conductance channel. The voltage control of conductance arose from the electric field driving monazomycin molecules at the membrane surface into the membrane and thus affecting the number of channels that were formed [2].
References:
[1] Bamberg E, Janko K. Single channel conductance at lipid bilayer membranes in presence of monazomycin[J]. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1976, 426(3): 447-450.
[2] Muller R U, Finkelstein A. Voltage-dependent conductance induced in thin lipid membranes by monazomycin[J]. The Journal of general physiology, 1972, 60(3): 263-284.
| Cas No. | 11006-31-8 | SDF | |
| المرادفات | Takacidin,U-0142 | ||
| Chemical Name | 48-(7-amino-1-methylheptyl)-8,10,16,20,24,26,28,32,36,38,40,42,44,46-tetradecahydroxy-23-(α-D-mannopyranosyloxy)-9,15,17,19,21,25,31,33,39,41,47-undecamethyl-oxacyclooctatetraconta-13,17,21,29-tetraen-2-one | ||
| Canonical SMILES | OC(CC(C(C(C(O[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)C(CO)O1)/C=C(C)/C(O)C(C)/C=C(C)/C(O)C(C)/C=C/CCC(O)C(C)C(O)CCCCCC2=O)O)C)O)/C=C/C(C)C(O)C(C)CCC(O)CC(O)C(C)C(O)C(C)C(O)CC(O)CC(O)C(C)C(O2)C(C)CCCCCCN | ||
| Formula | C72H133NO22 | M.Wt | 1364.8 |
| الذوبان | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 732.7 μL | 3.6635 mL | 7.3271 mL |
| 5 mM | 146.5 μL | 732.7 μL | 1.4654 mL |
| 10 mM | 73.3 μL | 366.4 μL | 732.7 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)