MSN-125 |
| رقم الكتالوجGC61096 |
MSN-125 هو مثبط فعال لتجمع Bax و Bak. يمنع MSN-125 اختراق الغشاء الخارجي للميتوكوندريا (MOMP) بـ IC50 4 μم. يثبط MSN-125 بشكل قوي البرامج المحفزة على Bax / Bak في HCT-116 ، خلايا BMK ، والخلايا العصبية القشرية الأولية ، كما يحمي الخلايا العصبية من التسمُّم بالغلوتامات.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1592908-16-1
Sample solution is provided at 25 µL, 10mM.
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MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity[1].
MSN-125 inhibits tBid/Bax-mediated MOMP in a concentration-dependent manner[1].
[1]. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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