Naphthofluorescein (Synonyms: CCG 8295) |
| رقم الكتالوجGC44313 |
يمنع النفثوفلوريسئين التفاعل بين HIF-1 والنعناع 3 ، ويثبط نافثوفلوريسئين نشاط HIF-1 المعتمد على Mint3 وتحلل السكر في الخلايا السرطانية والضامة دون حدوث سمية خلوية في المختبر وتأثير ضار في الجسم الحيالنفثوفلوريسئين هو أيضًا مسبار حساس لدرجة الحموضة الفلورية يمكن استخدامه لتصوير Cerenkov الوظيفي
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Cas No.: 61419-02-1
Sample solution is provided at 25 µL, 10mM.
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Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 μM). It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP), resulting in decreased levels of active MT1-MMP. This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP. Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080. The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined.
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