NAV 26 |
| رقم الكتالوجGC50071 |
NAV 26 (المركب 26) عبارة عن مانع انتقائي لقناة الصوديوم Nav1.7 مع IC50 يبلغ 0.37 ميكرومتر
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Cas No.: 1198160-14-3
Sample solution is provided at 25 µL, 10mM.
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Selective Nav1.7 channel blocker (IC50 = 370 nM). Exhibits >85-fold selectivity for Nav1.7 over Nav1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.
Macsari et al (2012) 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 55 6866 PMID:22770500
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