Ned K |
رقم الكتالوجGC50308 |
Ned K هو مضاد حمض النيكوتين الأدينين ثنائي النوكليوتيد (NAADP).
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Cas No.: 2250019-90-8
Sample solution is provided at 25 µL, 10mM.
NAADP inhibitor. Prevents Ca2+ oscillations in rat cardiomyocytes in vitro during simulated ischemia and reperfusion, but exhibits no significant effect on Ca2+ sparks. Significantly reduces infarct size in rat cardiac ischemia/reperfusion model in vivo.
Davidson et al (2015) Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovasc.Res. 108 357 PMID:26395965
Average Rating: 5
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