NPD-001 |
| رقم الكتالوجGC64844 |
NPD-001 هو مثبط قوي مثقبي بروسي فسفودايستراز TbrPDEB1 و TbrPDEB2 ، بقيم IC50 تبلغ 4 و 3 نانومتر ، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 469863-16-9
Sample solution is provided at 25 µL, 10mM.
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NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM[1].
[1]. Veerman J, et al. Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals. Bioorg Med Chem. 2016 Apr 1;24(7):1573-81.
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