NU6300 |
| رقم الكتالوجGC32829 |
NU6300 هو مثبط CDK2 تفاعلي وجزئي القطبية ولا يمكن عكسه، كما أنه منافس لـ ATP بتركيز IC50 قدره 0.16 ميكرومولار. يمكن استخدام NU6300 في الأبحاث المتعلقة بالدورة الخلوية والتشفير للخلايا الحقيقية (eukaryotic).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2070015-09-5
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
NU6300 is the first covalent ATP-competitive CDK2 inhibitor.IC50 value:Target: CDK2in vitro: NU6300 is a covalent CDK2 inhibitor that illustrates the potential of using vinyl sulfones to mediate irreversible inhibition. NU6300 blocks the inhibitor binding site. The effect was time dependent and relatively slow, with less than 50% reduction of the apparent binding capacity in 20 hr.
[1]. Anscombe E, et al. Identification and Characterization of an Irreversible Inhibitor of CDK2. Chem Biol. 2015 Sep 17;22(9):1159-1164.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *