>>Signaling Pathways>> DNA Damage/DNA Repair>> CDK>>NU6300

NU6300

Catalog No.GC32829

NU6300는 0.16 μM의 IC50 값을 가진 공유결합, 불가역 및 ATP 경쟁적인 CDK2 억제제입니다. NU6300은 유핵 세포주기 및 전사 관련 연구에 사용될 수 있습니다.

Products are for research use only. Not for human use. We do not sell to patients.

NU6300 Chemical Structure

Cas No.: 2070015-09-5

Size 가격 재고 수량
10mM (in 1mL DMSO)
US$354.00
재고 있음
1mg
US$145.00
재고 있음
5mg
US$321.00
재고 있음
10mg
US$459.00
재고 있음
50mg
US$1,379.00
재고 있음
100mg
US$1,930.00
재고 있음

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고객 리뷰

Based on customer reviews.

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

NU6300 is the first covalent ATP-competitive CDK2 inhibitor.IC50 value:Target: CDK2in vitro: NU6300 is a covalent CDK2 inhibitor that illustrates the potential of using vinyl sulfones to mediate irreversible inhibition. NU6300 blocks the inhibitor binding site. The effect was time dependent and relatively slow, with less than 50% reduction of the apparent binding capacity in 20 hr.

[1]. Anscombe E, et al. Identification and Characterization of an Irreversible Inhibitor of CDK2. Chem Biol. 2015 Sep 17;22(9):1159-1164.

리뷰

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Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

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