PFI-90 |
| رقم الكتالوجGC62678 |
PFI-90 هو مثبط انتقائي للهيستون ديميثيلاز (KDM3B) الذي يثبط عمل PAX3-FOXO1يحفز PFI-90 موت الخلايا المبرمج والتمايز العضلي ، مما يؤدي إلى زيادة موت الخلاياPFI-90 لديه القدرة على النشاط المضاد للورم(براءة اختراع WO2021101929A1)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 53995-62-3
Sample solution is provided at 25 µL, 10mM.
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PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).
PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μμ; 24 hours) increases apoptosis in RH4 and SCMC cells[1].
[1]. KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.
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