PFI-90 |
| Catalog No.GC62678 |
PFI-90은 PAX3-FOXO1 작용을 억제하는 히스톤 데메틸라제(KDM3B)의 선택적 억제제입니다. PFI-90은 세포 사멸과 근세포 분화를 유도하여 세포 사멸을 증가시킵니다. PFI-90은 항종양 활성 가능성이 있습니다. (특허 WO2021101929A1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 53995-62-3
Sample solution is provided at 25 µL, 10mM.
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PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).
PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μμ; 24 hours) increases apoptosis in RH4 and SCMC cells[1].
[1]. KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.
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