PQ 69 |
| رقم الكتالوجGC50149 |
PQ 69 هو أحد مضادات مستقبلات الأدينوزين A1 القوية والانتقائية مع نشاط ناهض معكوس.
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Cas No.: 910045-32-8
Sample solution is provided at 25 µL, 10mM.
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Potent and selective A1 receptor inverse agonist. Exhibits high binding affinity at A1 receptor (Ki values are 0.07 and 0.96 nM for rat and human receptors respectively). Reduces basal [35S]-GTPγS binding 44.6% (IC50 = 0.19 nM). Antagonizes the effects of A1 agonist R-PIA (IC50 = 18.3 nM) and exhibits competitive antagonism on CCPA-induced tracheal contractions ex vivo. Displays 217- fold selectively over hA2A receptor and >1000-fold selectivity over hA3 receptor.
Lu et al (2014) PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. Purinergic Signal. 10 619 PMID:25248972
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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