Prednisolone Phosphate (sodium salt) (Synonyms: Disodium Prednisolone 21Phosphate, Prednisolone Sodium Phosphate) |
رقم الكتالوجGC44678 |
فوسفات بريدنيزولون (ملح الصوديوم) عبارة عن قشرانيات سكرية اصطناعية ذات خصائص مضادة للالتهابات ومعدلة للمناعة.
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Cas No.: 125-02-0
Sample solution is provided at 25 µL, 10mM.
Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid ReceptorPrednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2].
References:
[1]. Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33(12): p. 1684-95.
[2]. http://en.wikipedia.org/wiki/Prednisolone
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