Propargyl-PEG2-amine |
| رقم الكتالوجGC61207 |
Propargyl-PEG2-amine عبارة عن رابط ADC غير قابل للكسر يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs)Propargyl-PEG2-amine عبارة عن رابط PROTAC قائم على PEG يمكن استخدامه في تركيب PROTACs
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Cas No.: 944561-44-8
Sample solution is provided at 25 µL, 10mM.
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Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Changchun Wang, et al. A kind of antibody coupling matter and its construction method containing boron ester units polymer. CN108721642A. [2]. Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.
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