R788 disodium hexahydrate |
| رقم الكتالوجGC15709 |
فوستاماتينيب (R788) سداسي هيدرات ثنائي الصوديوم هو الدواء الأولي الفموي للمركب النشط R406.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 914295-16-2
Sample solution is provided at 25 µL, 10mM.
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Fostamatinib disodium hexahydrate (R788 disodium hexahydrate), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
References:
[1]. Braselmann, S., et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther, 2006. 319(3): p. 998-1008.
[2]. Chen, L., et al., SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood, 2008. 111(4): p. 2230-7.
[3]. Suljagic, M., et al., The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling. Blood, 2010. 116(23): p. 4894-905.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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