Rabeprazole |
| رقم الكتالوجGC16645 |
رابيبرازول (LY307640) هو من الجيل الثاني من مثبطات مضخة البروتون (PPI) الذي يعطل المعدة بشكل لا رجعة فيه H+ / K+-ATPase.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 117976-89-3
Sample solution is provided at 25 µL, 10mM.
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Rabeprazole is an antiulcer drug in the class of proton pump inhibitors.Target: Proton PumpRabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds.
References:
[1]. http://www.drugbank.ca/drugs/DB01129
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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