CPTH2 |
| رقم الكتالوجGC39365 |
CPTH2 هو مثبط قوي هيستون أسيتيل ترانسفيراز (HAT)يمنع CPTH2 بشكل انتقائي أستلة هيستون H3 بواسطة Gcn5يحفز CPTH2 موت الخلايا المبرمج ويقلل من اجتياح خط خلية سرطان كلوي خلوي واضح (ccRCC) من خلال تثبيط أستيل ترانسفيراز p300 (KAT3B)
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Cas No.: 357649-93-5
Sample solution is provided at 25 µL, 10mM.
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CPTH2 is a potent histone acetyltransferase (HAT) inhibitor and selectively inhibits the acetylation of histone H3 by recombinant human Gcn5 in a substrate-competive manner. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2].
[1]. Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44. [2]. Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. J Med Chem. 2009 Jan 22;52(2):530-6.
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