RAS inhibitor Abd-7 |
| رقم الكتالوجGC62421 |
مثبط RAS Abd-7 ، مركب قوي ملزم لـ RAS (Kd = 51 نانومتر) ، هو مثبط تفاعل البروتين البروتيني المؤثر لـ RAS (PPI)يتفاعل مثبط RAS Abd-7 مع RAS داخل الخلايا ، ويمنع تفاعلات المستجيب RAS ويمنع الإشارات الداخلية المعتمدة على RASمثبط RAS Abd-7 يضعف PPI لبروتينات KRAS المتحولة المختلفة مع PI3K و CRAF و RALGDS بالإضافة إلى NRAS Q61H و HRAS G12V
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Cas No.: 2351843-48-4
Sample solution is provided at 25 µL, 10mM.
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RAS inhibitor Abd-7, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V[1].
RAS inhibitor Abd-7 (0-20 μM; 24-48 hours) is a cell-potent inhibitor affecting the viability of cancer cell lines in a single digit to low micromolar range[1].
[1]. Quevedo CE, et al. Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun. 2018;9(1):3169. Published 2018 Aug 9.
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