RAS inhibitor Abd-7 |
| カタログ番号GC62421 |
強力な RAS 結合化合物 (Kd = 51 nM) である RAS 阻害剤 Abd-7 は、RAS エフェクタータンパク質間相互作用 (PPI) 阻害剤です。 RAS 阻害剤 Abd-7 は、細胞内で RAS と相互作用し、RAS エフェクター相互作用を防ぎ、内因性の RAS 依存性シグナル伝達を阻害します。 RAS 阻害剤 Abd-7 は、PI3K、CRAF、RALGDS、および NRAS Q61H と HRAS G12V によって、さまざまな変異型 KRAS タンパク質の PPI を阻害します。
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Cas No.: 2351843-48-4
Sample solution is provided at 25 µL, 10mM.
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RAS inhibitor Abd-7, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V[1].
RAS inhibitor Abd-7 (0-20 μM; 24-48 hours) is a cell-potent inhibitor affecting the viability of cancer cell lines in a single digit to low micromolar range[1].
[1]. Quevedo CE, et al. Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun. 2018;9(1):3169. Published 2018 Aug 9.
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