Chromatin/Epigenetics
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Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Research Areas
- Bromodomain(44)
- Aurora Kinase(74)
- DNA Methyltransferase(43)
- HDAC(249)
- Histone Acetyltransferases(98)
- Histone Demethylases(120)
- Histone Methyltransferase(277)
- HIF(127)
- JAK(188)
- PARP(162)
- Pim(35)
- Protein Ser/Thr Phosphatases(23)
- RNA Polymerase(4)
- Sirtuin(87)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(20)
- Epigenetic Reader Domain(292)
- MicroRNA(33)
- Protein Arginine Deiminase(17)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(43)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(16)
- METTL3(4)
- WDR5(8)
- TET Protein(2)
- HuR(2)
- SF3B1(2)
Products Related to Chromatin/Epigenetics(1939)
- GC43321CPTH6 (hydrobromide)CAS: 2321332-57-2Purity: >98.00%
CPTH6 is a thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP.
- GC43354CysmethynilCAS: 851636-83-4Purity: >98.00%
Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis.
- GC43406Delphinidin (chloride)CAS: 528-53-0Purity: >98.00%
دلفينيدين (كلوريد) ، وهو أنثوسيانيدين ، معزول عن التوت والنبيذ الأحمر.
- GC43651F-Amidine (trifluoroacetate salt)CAS: 877617-46-4Purity: >95.00%
F-amidine is an inhibitor of protein arginine deiminases (PADs) that is selective for PAD1 and PAD4 (IC50s = 29.5, 350, and 21.6 μM for PAD1, PAD3, and PAD4 in vitro, respectively).
- GC43715Furamidine (hydrochloride)CAS: 55368-40-6Purity: >98.00%
فوراميدين (هيدروكلوريد) (DB75 ثنائي هيدروكلوريد) هو مثبط انتقائي للبروتين أرجينين ميثيل ترانسفيراز 1 (PRMT1) مع IC50 من 9.4 μ ؛ M.
- GC43787GSK106 (hydrochloride)CAS: 1652591-82-6Purity: >98.00%
GSK106 (هيدروكلوريد) هو عنصر تحكم غير نشط لمثبطات PAD4 الانتقائية ، GSK484 و GSK199.
- GC43788GSK121 (trifluoroacetate salt)CAS: 1652591-80-4Purity: >98.00%
GSK-121 ثلاثي فلورو أسيتات مثبط انتقائي لـ PAD4.
- GC43789GSK199 (hydrochloride)CAS: 1549811-53-1Purity: >98.00%
GSK199 (هيدروكلوريد) هو مثبط PAD4 قابل للانعكاس وانتقائي مع IC50 من 200 نانومتر في حالة عدم وجود الكالسيوم.
- GC43792GSK-J2 (sodium salt)CAS: 2108665-15-0Purity: >90.00%
The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.
- GC43794GSK-J5 (hydrochloride)CAS: 1797983-32-4Purity: >95.00%
GSK-J5 (هيدروكلوريد) هو مشتق استر نفاذي للخلايا من GSK J2 ، غير نشط. GSK-J5 (هيدروكلوريد) هو أيضًا أيزومر لـ GSK-J4 وغالبًا ما يستخدم كمجموعة سلبية.
- GC43826Histone H2A (1-20) (human, mouse, rat, bovine) (trifluoroacetate salt)Purity: >95.00%
Histone H2A (1-20) is an N-terminal peptide fragment of histone H2A that corresponds to amino acid residues 2-21 of the human histone H2A sequence.
- GC43827Histone H3 (1-15) (Phospho-Ser10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)Purity: >95.00%
Histone H3 (1-15) (phospho-Ser10) is a peptide fragment that corresponds to amino acid residues 2-16 of the human histone H3 sequence.
- GC43828Histone H3 (1-18)-WC amide (trifluoroacetate salt)Purity: >95.00%
Histone H3 (1-18)-WC amide is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-19 of the human histone H3 sequence and also contains a tryptophan and cysteine at its C-terminus.
- GC43829Histone H3 (1-20) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)Purity: >95.00%
Histone H3 (1-20) is an N-terminal fragment of histone H3 that corresponds to amino acid residues 2-21 of the human histone H3 sequence.
- GC43830Histone H3 (21-44) (Phospho-Ser28) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)Purity: >95.00%
Histone H3 (21-44) (phospho-Ser28) is a peptide fragment that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence.
- GC43831Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)Purity: >95.00%
Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker.
- GC43832Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)Purity: >95.00%
Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence and is biotinylated via a C-terminal GK linker.
- GC43833Histone H3 (23-34) (human, mouse, rat, bovine) (trifluoroacetate salt)Purity: >95.00%
Histone H3 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences.
- GC43834Histone H3 (5-23) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)Purity: >95.00%
Histone H3 (5-23) is a peptide fragment of histone H3 that corresponds to amino acid residues 6-24 of the human histone H3.3 sequence.
- GC43835Histone H3 (5-23) (yeast) (trifluoroacetate salt)Purity: >95.00%
Histone H3 (5-23) is a peptide fragment of histone H3 that corresponds to amino acid residues 6-24 of S.
- GC43837Histone H3 Peptide Substrate (1-21)Purity: >95.00%
Histone H3 undergoes many modifications including acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.
- GC43839Histone H3K14Ac (1-19) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)Purity: >95.00%
Histone H3K14Ac (1-19) is a peptide fragment of histone H3 that corresponds to amino acid residues 2-20 of the human histone H3 sequence.
- GC43840Histone H3K14Ac (9-19) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)Purity: >95.00%
Histone H3K14Ac (9-19) is a peptide fragment of histone H3 that corresponds to amino acid residues 10-20 of the human histone H3 sequence.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC43321 | CPTH6 (hydrobromide) | 2321332-57-2 | >98.00% | |
CPTH6 is a thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP. | ||||
| GC43354 | Cysmethynil | 851636-83-4 | >98.00% | |
Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. | ||||
| GC43406 | Delphinidin (chloride) | 528-53-0 | >98.00% | |
دلفينيدين (كلوريد) ، وهو أنثوسيانيدين ، معزول عن التوت والنبيذ الأحمر. | ||||
| GC43651 | F-Amidine (trifluoroacetate salt) | 877617-46-4 | >95.00% | |
F-amidine is an inhibitor of protein arginine deiminases (PADs) that is selective for PAD1 and PAD4 (IC50s = 29.5, 350, and 21.6 μM for PAD1, PAD3, and PAD4 in vitro, respectively). | ||||
| GC43715 | Furamidine (hydrochloride) | 55368-40-6 | >98.00% | |
فوراميدين (هيدروكلوريد) (DB75 ثنائي هيدروكلوريد) هو مثبط انتقائي للبروتين أرجينين ميثيل ترانسفيراز 1 (PRMT1) مع IC50 من 9.4 μ ؛ M. | ||||
| GC43787 | GSK106 (hydrochloride) | 1652591-82-6 | >98.00% | |
GSK106 (هيدروكلوريد) هو عنصر تحكم غير نشط لمثبطات PAD4 الانتقائية ، GSK484 و GSK199. | ||||
| GC43788 | GSK121 (trifluoroacetate salt) | 1652591-80-4 | >98.00% | |
GSK-121 ثلاثي فلورو أسيتات مثبط انتقائي لـ PAD4. | ||||
| GC43789 | GSK199 (hydrochloride) | 1549811-53-1 | >98.00% | |
GSK199 (هيدروكلوريد) هو مثبط PAD4 قابل للانعكاس وانتقائي مع IC50 من 200 نانومتر في حالة عدم وجود الكالسيوم. | ||||
| GC43792 | GSK-J2 (sodium salt) | 2108665-15-0 | >90.00% | |
The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. | ||||
| GC43794 | GSK-J5 (hydrochloride) | 1797983-32-4 | >95.00% | |
GSK-J5 (هيدروكلوريد) هو مشتق استر نفاذي للخلايا من GSK J2 ، غير نشط. GSK-J5 (هيدروكلوريد) هو أيضًا أيزومر لـ GSK-J4 وغالبًا ما يستخدم كمجموعة سلبية. | ||||
| GC43806 | HC Toxin | 83209-65-8 | >98.00% | |
HC Toxin ، رباعي ببتيد دوري ، هو مثبط قوي لـ HDAC مع IC 50 من 30 نانومتر. يحفز HC Toxin موت الخلايا المبرمج للخلايا السرطانية وله تأثيرات مضادة للسرطان. | ||||
| GC43826 | Histone H2A (1-20) (human, mouse, rat, bovine) (trifluoroacetate salt) | - | >95.00% | |
Histone H2A (1-20) is an N-terminal peptide fragment of histone H2A that corresponds to amino acid residues 2-21 of the human histone H2A sequence. | ||||
| GC43827 | Histone H3 (1-15) (Phospho-Ser10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
Histone H3 (1-15) (phospho-Ser10) is a peptide fragment that corresponds to amino acid residues 2-16 of the human histone H3 sequence. | ||||
| GC43828 | Histone H3 (1-18)-WC amide (trifluoroacetate salt) | - | >95.00% | |
Histone H3 (1-18)-WC amide is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-19 of the human histone H3 sequence and also contains a tryptophan and cysteine at its C-terminus. | ||||
| GC43829 | Histone H3 (1-20) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
Histone H3 (1-20) is an N-terminal fragment of histone H3 that corresponds to amino acid residues 2-21 of the human histone H3 sequence. | ||||
| GC43830 | Histone H3 (21-44) (Phospho-Ser28) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
Histone H3 (21-44) (phospho-Ser28) is a peptide fragment that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence. | ||||
| GC43831 | Histone H3 (21-44)-GK-biotin (trifluoroacetate salt) | - | >95.00% | |
Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker. | ||||
| GC43832 | Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) | - | >95.00% | |
Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence and is biotinylated via a C-terminal GK linker. | ||||
| GC43833 | Histone H3 (23-34) (human, mouse, rat, bovine) (trifluoroacetate salt) | - | >95.00% | |
Histone H3 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences. | ||||
| GC43834 | Histone H3 (5-23) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
Histone H3 (5-23) is a peptide fragment of histone H3 that corresponds to amino acid residues 6-24 of the human histone H3.3 sequence. | ||||
| GC43835 | Histone H3 (5-23) (yeast) (trifluoroacetate salt) | - | >95.00% | |
Histone H3 (5-23) is a peptide fragment of histone H3 that corresponds to amino acid residues 6-24 of S. | ||||
| GC43837 | Histone H3 Peptide Substrate (1-21) | - | >95.00% | |
Histone H3 undergoes many modifications including acetylation, methylation, and phosphorylation that are important for regulation of gene transcription. | ||||
| GC43839 | Histone H3K14Ac (1-19) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
Histone H3K14Ac (1-19) is a peptide fragment of histone H3 that corresponds to amino acid residues 2-20 of the human histone H3 sequence. | ||||
| GC43840 | Histone H3K14Ac (9-19) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
Histone H3K14Ac (9-19) is a peptide fragment of histone H3 that corresponds to amino acid residues 10-20 of the human histone H3 sequence. | ||||