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Chromatin/Epigenetics

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Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Research Areas

Products Related to Chromatin/Epigenetics(1791)

  • GC81024 structure
    GC81024PROTAC RNF4 degrader-1
    Purity: >98.00%

    PROTAC RNF4 degrader-1 is a RNF4 PROTAC degrader ( K d = 64.5 nM) that degrades RNF4 via the ubiquitin-proteasome system.

  • GC81026 structure
    GC81026PROTAC SKP2 Degrader-1
    CAS: 3120650-15-6
    Purity: >99.50%

    PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM.

  • GC81027 structure
    GC81027PROTAC HIF-1α degrader-2
    CAS: 3095636-64-6
    Purity: >98%

    PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex.

  • GC81031 structure
    GC81031NEO-811
    CAS: 3084635-77-5
    Purity: >98%

    NEO-811 is a selective and orally active ARNT (HIF-1β) molecular glue degrader.

  • GC81312 structure
    GC81312PARP1/c-Met-IN-3
    CAS: 3123529-62-1
    Purity: >98%

    PARP1/c-Met-IN-3 (Compound L19) is a selective c-Met and PARP1 inhibitor, with an IC 50 of 5.4 nM against c-Met and an IC 50 of 3.7 nM against PARP1.

  • GC81357 structure
    GC81357JZY3032
    Purity: >98.00%

    JYZ3032 is an orally active super inhibitor of androgen receptor ( AR ) and p300/CBP.

  • GC81400 structure
    GC81400Adenosine-3',5'-bisphosphate ammonium solution (100 mM)
    Purity: >99.00%

    Adenosine-3',5'-bisphosphate ammonium is a XRN1 inhibitor ( IC 50 = 36 nM).

  • GC81447 structure
    GC81447ALDOA-IN-1
    Purity: >98.00%

    ALDOA-IN-1 is an aldolase A (ALDOA) inhibitor.

  • GC81481 structure
    GC81481SKLB06489
    Purity: >98%

    SKLB06489 is a selective and orally active inhibitor of type I PRMT enzymes, with IC 50 values of 64.55 nM ( PRMT1 ), 4.21 nM ( PRMT6 ), and 51.27 nM ( PRMT8 ).

  • GC81499 structure
    GC81499CT-179
    CAS: 1996636-69-1
    Purity: >99.50%

    CT-179 is a brain-penetrant and orally active OLIG2 inhibitor with a human IC 50 of 1250 nM.

  • GC81512 structure
    GC81512dCDK9-202
    Purity: >98.50%

    dCDK9-202 is a CDK9 PROTAC degrader with a DC 50 of 3.5 nM.

  • GC81535 structure
    GC81535Etedesiran
    Purity: >93.00%

    Etedesiran is a component of the AOC drug Delpacibart etedesiran, formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK ) with SMCC linker.

  • GC81536 structure
    GC81536Braxlosiran
    Purity: >95.00%

    Braxlosiran is a component of the AOC reagent Delpacibart braxlosiran, consisting of an siRNA targeting DUX4 (double homeobox protein) and SMCC linker.

  • GC81557 structure
    GC81557Zilebesiran sodium
    CAS: 2380166-34-5
    Purity: >94.50%

    Zilebesiran (AD-85481; ALN-AGT) sodium is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent.

  • GC81584 structure
    GC815842-Amino-2-deoxy-D-glucopyranose
    CAS: 90-77-7
    Purity: >98.00%

    2-Amino-2-deoxy-D-glucopyranose is an isomeric form of Glucosamine.

  • GC81594 structure
    GC81594TLSC702
    CAS: 748786-57-4
    Purity: >95.50%

    TLSC702 is a human glyoxalase I ( hGLO I ) inhibitor with an IC 50 of 2.0 μM.

  • GC81595 structure
    GC81595BCS12
    CAS: 329719-71-3
    Purity: >99.50%

    BCS12 is a CAIX inhibitor.

  • GC81602 structure
    GC81602Glucosamine sulfate potassium chloride
    CAS: 1296149-08-0
    Purity: >98.00%

    Glucosamine sulfate potassium chloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement.

  • GC81628 structure
    GC81628Nicotinamide- 13 C, 15 N
    Purity: >98.50%

    Nicotinamide - 13 C, 15 N (Niacinamide- 13 C, 15 N) is the 13 C- and 15 N-labeled Nicotinamide.

  • GC81637 structure
    GC81637EBET-1593
    CAS: 3031540-97-0
    Purity: >98%

    EBET-1593 is a BET PROTAC degrader.

  • GC81639 structure
    GC81639SH-26
    Purity: >98%

    SH-26 is a PHD1 PROTAC degrader with DC 50 s of 1.06 μM, 4.16 μM and 4.91 μM in MDA-MB-231, HepG2 and HEK-293T cells, respectively.

  • GC81658 structure
    GC81658FAM-hsa-miR-147b-5p mimic
    Purity: >98.00%

    FAM-hsa-miR-147b-5p mimic is a FAM-labeled hsa-miR-147b-5p mimic.

  • GC81659 structure
    GC81659GAPDH Positive Control siRNA (Human)
    Purity: >98.00%

    GAPDH Positive Control siRNA (Human), a siRNA product, is a human GAPDH siRNA positive control.

  • GC81660 structure
    GC81660GAPDH siRNA Positive Control (Mouse/Rat)
    Purity: >98.00%

    GAPDH siRNA Positive Control (Mouse/Rat), a siRNA product, is a mouse/rat GAPDH siRNA positive control.