Chromatin/Epigenetics

MKI-3 is a selective microtubule-associated serine/threonine kinase-like ( MASTL ) inhibitor with an IC 50 of 5.72 nM and a K d of 1.89 nM.

Endosidin7 is a specific inhibitor for plant callose deposition during cytokinesis.

GDP-azido-fucose disodium is a glycoengineering tool.

SA91-0178 is a METTL1 inhibitor.

(R)-I-BET762 carboxylic acid (Standard) is the analytical standard of (R)-I-BET762 carboxylic acid.

DDO3602 is a PARP1 HSPTAC ( HSP90 -mediated proteolysis-targeting chimera) degrader, with a DC 50 of 490.3 nM against PARP1; its K d values for PARP1 and HSP90 are 66.5 nM and 1.64 nM, respectively.

HDAC11-IN-5 is a selective, potent and orally active HDAC11 inhibitor with an IC 50 of 0.021 μM.

4-Chloro-N-methylpicolinamide -d 3 is the deuterated-labeled 4-Chloro-N-methylpicolinamide.

Histone H4 peptide substrate (1-21) acetate is a PAD4 peptide substrate.

Ac-ETDK(myr)-AMC acetate is a DLAT-derived ε-N-myristoyllysine peptide substrate for fatty-acid deacylase HDAC11, used in fluorescence-based HDAC11 activity assays.

CPTH2 -d 4 is the deuterated-labeled CPTH2.

NCP26 TFA is an ATP-competitive ProRS inhibitor (with a K D of 271 nM in the absence of proline, and a K D of 0.35 nM in the presence of 100 μM proline).

PROTAC CARM1 degrader-1 TFA is a highly selective CARM1 PROTAC degrader, with a DC 50 of 8.1 nM in MCF‑7 cells.

Temozolomide - 15 N (NSC 362856- 15 N) is the 15 N-labeled Temozolomide.

معيار داخلي لتحديد كمية بوساكونازول

مثبط PAD2

مثبط الببتيد لـ WHSC1

مختِّز النحاس (II) ومشتق من الميتفورمين

مُحَطِّم للبروتين NSD2

متابوليت من تيوبرونين

مثبط JAK2

J27644 هو مثبط لإنزيم تاريخ الأسيتيلة 6 (HDAC6؛ IC50 = 10 نانومتر).

YCH1899 هو مثبط لإنزيم البولي (أدينوزين دايفوسفات-رايبوز) بوليميراز 1 (PARP1) و PARP2 (IC50s = 1). إنه اختياري لـ PARP1 و PARP2 على حساب PARP3، -4، -5A، -5B، -6، -7، -10 ، و-12 (IC50s = 1-14.1 نانومتر).

Bayer 18 is a tyrosine kinase 2 (TYK2) inhibitor (IC50 = 18.7 nM).