Ro-0335 (Synonyms: VM 1500A) |
| رقم الكتالوجGC62223 |
RO-0335 هو مثبط جديد وفعال للنسخ العكسي ثنائي فينيل إيثر نونوكليوزيد (NNRTI)RO-0335 يثبط Wt HIV-1 مع IC 50 من 1.1 نانومتر والنشاط المحتفظ به (IC50 <100 نانومتر) مقابل 92٪ من عدد كبير من العزلات السريرية المقاومة لـ NNRTI
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Cas No.: 867365-76-2
Sample solution is provided at 25 µL, 10mM.
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RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates[1].
[1]. Javanbakht H, et al. In vitro resistance development for RO-0335, a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Antiviral Res. 2010;86(2):212-219.
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