SAICAR (Synonyms: Succino-AICAR) |
| رقم الكتالوجGC44867 |
SAICAR هو وسيط للتخليق الحيوي للنيوكليوتيدات de novo purine ، وينشط بيروفات كيناز isoform M2 (PKM2) بطريقة انتقائية ، مع EC50 من 0.3 مميحفز SAICAR PKM2 ويعزز بقاء الخلايا السرطانية في ظروف محدودة الجلوكوز
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Cas No.: 3031-95-6
Sample solution is provided at 25 µL, 10mM.
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SAICAR is an intermediate in the de novo purine nucleotide synthesis pathway. It is reported to stimulate pyruvate kinase isoform M2 and to promote cancer cell survival in conditions of limited glucose availability.[1]
Reference:
[1]. Keller, K.E., Tan, I.S., and Lee, Y.S. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. Science 338, 1069-1072 (2012).
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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