SAICAR (Synonyms: Succino-AICAR) |
| Catalog No.GC44867 |
SAICAR es un intermedio de la biosÍntesis de nucleÓtidos de purina de novo, activa la isoforma M2 de la piruvato quinasa (PKM2) de manera selectiva para las isoenzimas, con una CE50 de 0,3 mM. SAICAR estimula PKM2 y promueve la supervivencia de las células cancerosas en condiciones limitadas de glucosa.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3031-95-6
Sample solution is provided at 25 µL, 10mM.
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SAICAR is an intermediate in the de novo purine nucleotide synthesis pathway. It is reported to stimulate pyruvate kinase isoform M2 and to promote cancer cell survival in conditions of limited glucose availability.[1]
Reference:
[1]. Keller, K.E., Tan, I.S., and Lee, Y.S. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. Science 338, 1069-1072 (2012).
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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