SI-2 hydrochloride (Synonyms: EPH 116 hydrochloride) |
| رقم الكتالوجGC50307 |
SI-2 (EPH 116 hydrochloride) هو مثبط SRC-3 واعد للغاية ، مع قيم IC50 من 3-20 نانومتر لموت خلايا سرطان الثدييتمتع SI-2 (EPH 116 hydrochloride) بسمية محسّنة ومظهر حركي دوائي محسّن بشكل كبير ، مع توافر مقبول عن طريق الفم
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1992052-49-9
Sample solution is provided at 25 µL, 10mM.
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Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.
Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID:27084884
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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