SI-2 hydrochloride (Synonyms: EPH 116 hydrochloride) |
| Catalog No.GC50307 |
SI-2 (clorhidrato de EPH 116) es un inhibidor de SRC-3 (PPI) muy prometedor, con valores de IC50 de 3-20 nM para la muerte de células de cÁncer de mama. SI-2 (clorhidrato de EPH 116) tiene una toxicidad y un perfil farmacocinético muy mejorados, con una disponibilidad oral aceptable.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1992052-49-9
Sample solution is provided at 25 µL, 10mM.
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Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.
Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID:27084884
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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