Simeprevir (sodium salt) |
| رقم الكتالوجGC44891 |
Simeprevir (TMC435 ؛ TMC435350) الصوديوم هو مثبط إنزيم بروتياز NS3 / 4A عن طريق الفم ، قوي وعالي التحديد لفيروس التهاب الكبد الوبائي سي (HCV) مع Ki 0.36 نانومتر.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1241946-89-3
Sample solution is provided at 25 µL, 10mM.
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Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication. It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays. In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin . Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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