SK1-IN-1 |
| رقم الكتالوجGC33836 |
SK1-IN-1 هو مثبط قوي للكيناز سفينجوزين 1 (SPHK1) مع IC 50 من 58 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1218816-71-7
Sample solution is provided at 25 µL, 10mM.
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SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.
SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation[1].
[1]. Xiang Y, et al. Discovery of novel sphingosine kinase-1 inhibitors. Part 2. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4550-4.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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