Sparfosic acid trisodium |
| رقم الكتالوجGC39643 |
حمض سبارفوسيك ثلاثي الصوديوم هو عامل مضاد للاستقلاب في الحمض النووي ومثبط قوي لأسبارتات ترانسكاربامويل ترانسفيراز
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Cas No.: 70962-66-2
Sample solution is provided at 25 µL, 10mM.
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Sparfosic acid trisodium, is a potent inhibitor of aspartate transcarbamoyl transferase, with anti-tumor and antimetabolite activity. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis[1][2].
[1]. Wang J, et al. Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug. Int J Oncol. 2015 Aug;47(2):782-90. [2]. Angela D. Morris, et al. A New, Efficient, Two Step Procedure for the Preparation of the Antineoplastic Agent Sparfosic Acid
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