SSTC3 |
| رقم الكتالوجGC39637 |
SSTC3 عبارة عن منشط كازين كيناز 1α (CK1α) (Kd = 32 نانومتر) يمنع إشارات WNT (EC50 = 30 نانومتر)يُظهر SSTC3 الحد الأدنى من السمية المعدية المعوية مقارنة بالفئات الأخرى من مثبطات WNT
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Cas No.: 1242422-09-8
Sample solution is provided at 25 µL, 10mM.
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SSTC3 is a casein kinase 1α (CK1α) activator (Kd = 32 nM) that inhibits WNT signaling (EC50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors[1].
[1]. Li B, et al, Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Sci Signal. 2017 Jun 27;10(485). pii: eaak9916.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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